Featured Topics
Acute Migraine Treatment Tool
Acute Pain Management for People on Chronic Opioids
Anxiety Patient Booklet to Motivate Benzodiazepine Tapering
Asthma Action Plan trial- Self-Management- Quadruple ICS vs Usual Care- 2021
Asthma- Adult and Adolescent Newsletter 2021
Asthma Landmark Trials- Treatment of Mild or Intermittent Adult and Adolescent Asthma 2021
Asthma Options for Mild Adult and Adolescents- Color Comparison Chart
Asthma Q and A- Frequently Asked Questions 2021
Buprenorphine-Naloxone SUBOXONE for Chronic Pain Infographic
Buprenorphine-Naloxone SUBOXONE for Opioid Use Disorder Infographic
Buprenorphine-Naloxone- SUBOXONE for Opioid Use Disorder Oct 2022
Buprenorphine-Naloxone SUBOXONE for Opioid Use Disorder- QandA Oct 2022
CAPiTA- Community-Acquired Pneumonia Immunization Trial in Adults 2022
Chart Pearls 13th Ed, Aug 2021
COMET ICE- Sotrovimab XEVUDY Infusion for Mild-Moderate COVID-19 Outpatients-2022
Concomitant Chronic Pain and Opioid Use Concern
COVID-19- Prevention, Vaccines and Therapies for Outpatients
COVID-19 Trials- Tx of symptomatic outpatients at high risk for progression to severe COVID 2022
Cystic Fibrosis
DAPA-CKD- Dapagliflozin versus Placebo in Chronic Kidney Disease Jan 2021
Dementia risk in Affective Disorders using Benzodiazepines and Z-drugs-2021
Depression 2022
Depression- Antidepressant Evidence Summary
Depression- Approach to Stopping Antidepressants for Major Depressive Disorder
Depression- Cornerstones to Initiating Depression Treatment
Depression FAQs
Depression- Managing Inadequate Antidepressant Treatment Response
Depression- Mental Health Resource Toolkit
Depression- Prescription for Non-Drug Treatment
Depression- Questions about Antidepressants Patient Booklet
Depression- Questions about Antidepressants Patient Booklet- Black and White
Depression- Treatment of MDD in Children and Adolescents
Diabetes Mini-book Top Clinical Pearls
Diabetes Patient Booklet for Patients who have Type 2 Diabetes
Effect of 7 vs 14 days of Antibiotic Therapy on Resolution of Symptoms in male UTI 2022
EMPEROR-Preserved trial summary- Empagliflozin in Preserved Heart Failure Sep 2021
EMPEROR-Reduced trial summary- Empagliflozin in Heart Failure Oct 2020
EPIC-HR-Nirmatrelvir + Ritonavir PAXLOVID- Treatment of Unvaccinated COVID-19 Patients-2022
Fremanezumab AJOVY for Preventative Treatment of Chronic Migraine 2022
Harm Reduction
Harm Reduction Patient Booklet for Injecting Drugs
Head Lice and Scabies
Heart Failure- Art of Optimizing HF-rEF Medications
Heart Failure Newsletter- Heart Failure with Reduced Ejection Fraction 2020
Heart Failure Sick Day Plan Apr 2021
HF- Furosemide Sliding Scale 2020
HIV Medications and Drug Interactions Apr 2021
Maintenance or Discontinuation of Antidepressants in Primary Care (the ANTLER RCT) 2022
Medication Overuse Headache Patient Booklet
Medication Overuse Headache Patient Booklet-Black and White
Medication Overuse Headache Tool
Medication Overuse Headache Trial Summary 2022
Medications for Alcohol Use Disorder-AUD: Common questions for primary care providers
Migraine Prophylaxis Individualization of Therapy Colour Chart
Migraine Prophylaxis Tool
Migraine Q and A- Frequently Asked Questions 2022
Migraine Therapy Newsletter 2022
Novel-START trial summary- The Option of Budesonide-Formoterol in Mild Asthma- 2021
Opioid Use Disorder Colour Comparison Chart of Buprenorphine-Naloxone SUBOXONE and Methadone
PINETREE- Early Remdesivir VEKLURY to Prevent Progression to Severe COVID-19 in Outpatients-2022
PRACTICAL trial- Budesonide-Formoterol prn vs Scheduled Budesonide- Mild-to-Moderate Asthma 2021
Pre-exposure Prophylaxis (PrEP) for Prevention of HIV
PrEP and HIV Newsletter 2021
PrEP Infographic-Should I take a pill to prevent HIV
PROVENT- Tixagevimab–Cilgavimab EVUSHELD IM Pre-exposure Prophylaxis-2022
Risk of Dementia in Patients with Affective Disorders using Benzodiazepines and Z-drugs-Nov-2021
Risk of Dementia-in Affective Disorders using Benzodiazepines and Z-drugs-Nov-2021
RxFiles-Prescription for a Virus- Pediatric version
Sleep Diary Tool
STAR*D: Sequenced Treatment Alternatives for Relieving Depression 2022
Suboxone (Buprenorphine-Naloxone) Microdosing Initiation
Suboxone (Buprenorphine-Naloxone) Patient Booklet for Switching from Current Opioid
SYGMA 1 trial- Budesonide-Formoterol prn in Mild Asthma- 2021
SYGMA 2 trial- Budesonide-Formoterol prn vs Maintenance Budesonide in Mild Asthma- 2021
TACKLE- Tixagevimab–Cilgavimab EVUSHELD IM for Early Outpatient Treatment-2022
The Little Blue Puffer
Treating Opioid Use Disorder in Primary Care- Focus on Buprenorphine-Naloxone
What is new or changed
z How to activate PLUS App for Partnerships with URL referral
link to get acrobat reader

RxFiles 13th Edition

September 2021
Go to our RxFiles.ca Online Store
Books also available from:
* U of S Bookstore, Saskatoon 
* University book stores Canada
* Saskatoon City Hospital Gift Shop

Note: This website is designed for healthcare professionals. It is not intended to replace the relationship between patient & physician or health care provider.

Independent Drug Info / Academic Detailing:
...in the USA...Link to iDiS, RxFacts.org: 

... in Australia...Link to NPS: //www.nps.org.au/
Registration is now open for our February 11, 2023 annual online conference!

RxFiles Academic Detailing is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry.

A small taste of some of our tools:

Have you ever needed to ...

adjust the dose of warfarin?

pick an inhaler device for a COPD patient?

encourage a patient to start exercising?

check the spectrum of an antibiotic?

loosen diabetic targets for a frail older adult?

look up the target doses of ACEIs, ARBs, or beta-blockers in heart failure?

encourage a patient on opioids to consider tapering?

find out which antipsychotics have the lowest weight gain?

talk to a patient about cannabis use?

find out the number of years to continue a bisphosphonate?

pick an SSRI with the least anticholinergic effects?

compare relative pricing of different antimuscarinics?

critically appraise the DOAC trials?

safely switch from one antidepressant to another?

get an idea of weight gain differences between diabetes meds?

weigh the advantages and disadvantages of chronic pain medications?

find out if a medication is safe to crush in a patient with difficulty swallowing?

look up a generic birth control substitution?

Our program began in 1997 as a service to Saskatoon physicians. In 2000, the program was expanded to provide service to physicians throughout Saskatchewan. Efforts to keep our drug selection tools up to date resulted in the publication of the RxFiles Drug Comparison Charts book, beginning in 2001. Our book has become a practical tool for evidence-based and clinically relevant drug use information throughout Canada.

On our website, you will find our newsletter reviews, Q&As, Trial Summaries, and up-to-date RxFiles Comparison Charts and Geri-RxFiles Charts. The clinical relevance of these materials comes from their initial focus as academic detailing tools for the front-line practitioner wanting to provide the best possible drug therapy for their patients.

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Sleep Diary Prescription Pad
Product Image A useful tool for helping your patients with insomnia.