RxFiles Trial Summaries


We undertake a lot of critical appraisal to create our drug comparison charts. Selected insight from that appraisal is published here. 

Landmark Trial Collections

Hypertension

Lipids

Anemia

Diabetes:
CV Outcomes

Diabetes:
Glycemic Targets

Diabetes:
Insulin

Diabetes:
Lipids, BP, ASA, etc.

2020

VICTORIA

Vericiguat 10mg vs placebo in heart failure.

Vit D: Burt et al

Vitamin D 400 units vs 4,000 units vs 10,000 units in primary prevention of osteoporosis.

2019

DECLARE-TIMI 58

Dapagliflozin 10mg vs placebo in type 2 diabetes. 

CREDENCE

Canagliflozin 100mg vs placebo in type 2 diabetes with chronic kidney disease. 

DAPA-HF

Dapagliflozin 10mg vs placebo in heart failure. 

2018

SPACE

Opioids vs non-opioids in chronic pain. 

Opioids: Chang et al

Opioids vs non-opioids in acute pain. 

2017

SPS3 systolic BP

Lower vs higher systolic blood pressure in recent stroke.

PIONEER AF-PCI

Rivaroxaban + P2Y12 inhibitor vs rivaroxaban + DAPT vs warafrin + DAPT in a-fib & PCI. 

MATCH

Clopiodgrel + ASA vs clopidogrel alone in recent stroke or TIA. 

SPS3 antiplatelet

Clopidogrel + ASA vs ASA alone in recent stroke.

CHANCE

Clopiogrel + ASA vs ASA alone in minor stroke or TIA.

SHIFT

Ivabradine vs placebo in heart failure. 

LRTI: Little et al

Amoxicillin vs placebo in acute lower respiratory tract infection.

CAP-START

Beta-lactam vs beta-lactam + macrolide vs fluoroquinolone in community acquired pneumonia.

UTI: Gupta et al

Nitrofurantoin vs TMP/SMX in uncomplicated cystitis. 

SSTI: Talan et al

TMP/SMX vs placebo in uncomplicated skin abscess.

2016

ELIXA

Lixisenatide 20mcg vs placebo in type 2 diabetes.

EMPA-REG

Empagliflozin 10mg vs empagliflozin 25mg vs placebo in type 2 diabetes. 

IRIS

Pioglitazone 45mg vs placebo in recent stroke or TIA.

LEADER

Liraglutide 1.8mg vs placebo in type 2 diabetes. 

TECOS

Sitagliptin 100mg vs placebo in type 2 diabetes. 

DAPT

12 vs 30 months of dual antiplatelet therapy after drug-eluting stents. 

PCI-CLARITY

Clopidogrel vs placebo as pre-treatment before PCI. 

PCI-CURE

Clopidogrel + ASA vs ASA alone as pre-treatment before PCI.

PEGASUS-TIMI 54

Ticagrelor vs placebo in prior MI. 

PLATO

Ticagrelor vs clopidogrel in acute coronary syndrome. 

TRITON-TIMI 38

Prasugrel vs clopiodgrel in acute coronary syndrome. 

FLAME

Indacaterol + glycopyrronium vs salmeterol + fluticasone in COPD. 

SSTI: Cadena et al

Clindamycin vs TMP/SMX in uncomplicated skin infections.

2015

SPRINT

Higher vs lower blood pressure targets. 

IMPROVE-IT

Ezetimibe + simvastatin vs simvastatin alone in cardiovascular disease.

FIELD substudy

Fenofibrate 200mg vs placebo in patients with diabetes, by gender. 

PARADIGM-HF

Valsartan + sacubitril vs enalapril in heart failure.

2014

Smoking: Evins et al

Varenicline vs placebo for smoking cessation in patients with schizophrenia or bipolar disorder.

2013

SAVOR-TIMI 53

Saxagliptin vs placebo in type 2 diabetes. 

ASPIRE

ASA vs placebo to prevent VTE. 

RE-LY

Dabigatran vs warfarin in atrial fibrilation. 

WARFASA

ASA vs placebo following warfarin to prevent VTE. 

SENIOR

Solifenacin vs oxybutynin in overactive bladder in older adults with mild cognitive impairment.

SPREAD-DIMCAD

Metformin vs glipizide in type 2 diabetes. 

2012

RACE-II

Lenient vs strict rate control in atrial fibrillation. 

PALLAS

Dronedarone vs placebo in atrial fibrillation. 

ARISTOTLE

Apixiban vs warfarin in atrial fibrillation. 

ROCKET-AF

Rivaroxaban vs warfarin in atrial fibrillation. 

2011

SHARP

Simvastatin + ezetimibe vs placebo in chronic kidney disease. 

AIM-HIGH

Niacin + simvastatin vs placebo + simvastatin in cardiovascular disease. 

CATIE-AD

Olanzapine vs quetiapine vs risperidone vs placebo in Alzheimer's Disease.

Pain: Solomon et al

NSAIDs vs coxibs vs opioids in arthritis. 

Smoking: Singh et al

Varenicline vs placebo in smoking cessation & CV risk. 

Cough: Paul et al

Vapor rub vs petrolatum vs no treatment in kids with cough.

Hirsutism Landmark Trials

2010

ACCORD LIPID & BP

Aggresive vs standard diabetes targets. 

ARBs: Meta-analysis

Do ARBs increase the risk of cancer?

2009

RECORD

Rosiglitazone vs usual care in type 2 diabetes. 

ACTIVE A

ASA + clopidogrel vs ASA alone in atrial fibrillation. 

ACTIVE W

ASA + clopiodgrel vs warfarin in atrial fibrillation.

2008

ACCORD

Intensive vs standard glycemic control in type 2 diabetes. 

ADVANCE

Intensive vs standard glycemic control in type 2 diabetes. 

ACCOMPLISH

ACEI + amlodipine vs ACEI + hydrochlorothiazide in hypertension. 

ENHANCE

Simvastatin vs simvastatin + ezetimibe in familial hypercholesterolemia. 

JUPITER

Rosuvastatin 20mg vs placebo in cardiovascular disease. 

OAB: Kay et al

Darifenacin vs oxybutynin effects on memory/cognition.

2007

DREAM

Rosiglitazone 8mg vs placebo & ramipril 15mg vs placebo in type 2 diabetes. 

2006

IDEAL

Atorvastatin 80mg vs simvastatin 20-40mg in previous MI. 

SPARCL

Atorvastatin 80mg vs placebo in stroke prevention.

CHARISMA

Clopidogrel + ASA vs ASA alone in cardiovascular disease. 

Asthma Landmark Trials

2005

ASCOT-BPLA

Amlodipine vs atenolol in hypertension. 

2004

CARDS

Atorvastatin 10mg vs placebo in type 2 diabetes. 

PROVE IT-TIMI 22

Atorvastatin 80mg vs pravastatin 40mg in acute coronary sydnrome.

2003

ASCOT-LLA

Atorvastatin vs placebo for cardiovascular disease. 

CHARM

Candesartan vs placebo in heart failure.