RxFiles: Diabetes

rxfiles.ca/diabetes

A collection of our resources for the management of diabetes mellitus, including initiating or optimizing drug therapy, helpful clinical tools, and landmark trial summaries.

RxFiles Charts

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Screening, Diagnosis, & Approach to Treatment

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Antihyperglycemic (non-insulin) T2DM agents: Drug Comparison Chart

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Insulin Initiation, Titration, and Follow up in T2DM

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Insulin: Drug Comparison Chart

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Insulin Pen Devices

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Antihyperglycemic Diabetes Agents in T2DM: Outcomes Colour Comparison Summary Table

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PERSPECTIVES ON: Glycemic Targets

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Blood Glucose Monitoring: Hypoglycemia and Sick Day Management

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Blood Glucose Monitors

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Gestational Diabetes and T2DM in Pregnancy

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GERI-RxFILES: Type 2 Diabetes Management in Older Adults

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Diabetes: Modifiable Risk Factors for CV and Renal Protection

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PERSPECTIVES ON: Diabetes and the Kidneys

Clinical Tools

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Physical Activity Rx

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Blood Sugars in Older Adults

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Protecting the Kidneys - Sick Day Management

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SGLT2 Inhibitor Adverse Effects: Healthcare Provider Infographic

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GLP1 Agonists Adverse Effects: Healthcare Provider Infographic

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The Long Story Short

Trial Summaries and Landmark Trials

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CONFIDENCE

The Effect of Simultaneous Initiation of
Finerenone with Empagliflozin on UACR in CKD and T2DM

(2025)

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FLOW

The Effects of Semaglutide on Chronic Kidney Disease in
Patients with T2DM

(2024)

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Cardiovascular Outcome Trials of Newer Antihyperglycemic
Agents

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SELECT

Semaglutide versus Placebo in Patients with Obesity without
Diabetes

(2023)

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Diabetes Landmark Trials

RCT Evidence for Lipid, ASA, BP, and Prevention Trials

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Type 2 Diabetes Mellitus

Insulin Trials

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Glycemic Targets

Landmark Outcomes Trials

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Diabetes Landmark Outcome Trials

Glycemic Control & Prevention Summary

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DAPA-CKD

Dapagliflozin 10mg vs Placebo in Patients
with Chronic Kidney Disease, with or without Type 2 Diabetes

(2020)

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EMPEROR-Reduced

Empagliflozin 10mg versus Placebo in Patients with Heart
Failure & Reduced Ejection Fraction

(2020)

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DAPA-HF

Dapagliflozin versus Placebo in Patients with Heart Failure &
Reduced EF

(2019)

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DECLARE-TIMI 58

Dapagliflozin vs Placebo in T2DM + CVD/Major Risk Factors

(2019)

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LEADER

Liraglutide: Cardiovascular Outcomes and Mortality in Patients
with Type 2 Diabetes

(2016)

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ELIXA

Lixisenatide: Cardiovascular Outcomes and Mortality in Patients
with Type 2 Diabetes Mellitus and Acute Coronary Syndrome

(2015)

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TECOS

Sitagliptin: Cardiovascular Outcomes and Mortality in Patients
with Type 2 Diabetes Mellitus

(2015)

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EMPA-REG

Empagliflozin: Cardiovascular Outcomes and Mortality in Patients
with Type 2 Diabetes Mellitus

(2015)

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FIELD

Fenofibrate in Patients with Diabetes, by Gender

(2014)

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SAVOR-TIMI 53

Saxagliptin and Cardiovascular Outcomes in Patients with
Type 2 Diabetes Mellitus

(2013)

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ACCORD Lipid & BP Trial Overview

Cardiovascular Risk in Type 2 Diabetes Mellitus: Treatment
Strategies

(2010)

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RECORD

Rosiglitazone for cardiovascular outcomes in Type 2 Diabetes

(2009)

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ACCORD

Intensive versus Standard A1C Targets in Type 2 Diabetes

(2008)

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ADVANCE

Is intensive glucose control with a gliclazide-based regimen
better than standard glucose control with a non-gliclazide
based regimen in high-risk, but not too hard to control T2DM?

(2008)

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Rosiglitazone (Avandia) and Cardiovascular Risk -
To Be Concerned, Or Not To Be Concerned?

(2007)

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DREAM

Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication

(2006)

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CARDS

Collaborative Atorvastatin Diabetes Study: Primary Prevention of Cardiovascular Disease with Atorvastatin in Type 2 Diabetes

(2004)

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RxFiles Academic Detailing is part of the University of Saskatchewan and our main offices are situated on Treaty 6 Territory and the Homeland of the Métis.

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